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Bendit- Bendamustine

Bendamustine injection is used to treat chronic lymphocytic leukemia (CLL; a type of cancer of the white blood cells). Bendamustine injection is also used to treat a type of non-Hodgkins lymphoma (NHL: cancer that begins in a type of white blood cell that normally fights infection) that is slow spreading, but has continued to worsen during or after treatment with another medication. Bendamustine is in a class of medications called alkylating agents. It works by killing existing cancer cells and limiting the growth of new cancer cells.

Strength : 100 mg single dose vial
Dosages : Bendamustine comes as a powder to be added to fluid and injected intravenously (into a vein) over 30 minutes by a doctor or nurse in a medical office or hospital outpatient clinic. When bendamustine injection is used to treat CLL, it is usually injected once a day for 2 days, followed by 26 days when the medication is not given. This treatment period is called a cycle, and the cycle may be repeated every 28 days for as long as 6 cycles. When bendamustine injection is used to treat NHL, it is usually injected once a day for 2 days, followed by 19 days when the medication is not given. This treatment cycle may be repeated every 21 days for up to 8 cycles.
Overdose : May lead to:-
  • drowsiness
  • uncontrollable shaking of a part of the body
  • problems with coordination
  • seizures
  • difficulty breathing
  • rapid, irregular, or pounding heartbeat

Precautions & Warnings:

  • Doctor consultation suggested if the patient has liver or kidney problems.
  • Smoking reduces the effect of the medicine, so doctor must be informed if the patient uses tobacco products.
  • Not suitable for patients who are allergic to the medicine or mannitol.
  • Patients are advised not to get immunized or vaccinated without consulting the doctor.
  • Not suitable for pregnant women (Doctor consultation required)

Drug Interactions:

  • Carbamazepine, cimetidine, thiabendazole or a barbiturate such as amobarbital, butabarbital, mephobarbital, secobarbital or phenobarbital.
  • The risk of Bandit’s side effects may be increased by ciprofloxacin or fluvoxamine.
  • The effect of Bendit may be decreased by omeprazole.